The World Health Organization (WHO) has designated antimicrobial resistance as one of the top ten global challenges facing humanity. This is not surprising, because antimicrobials have been a cornerstone in modern human and veterinary medicine. As the efficacy of these drugs decreases due to resistance, simple infections might become problematic once again, harkening back to the pre-antibiotics era. In this article, the emergence of antimicrobial resistance in major foodborne bacterial pathogens will be highlighted, and its ramifications in relation to food safety will be discussed.

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