Developmentally neurotoxic chemicals are a diverse set of substances that have the potential to interfere with the normal development of the human nervous system. The potential for exposure to environmental chemicals to have adverse impacts on neurodevelopment led to the development of in vivo testing batteries starting in the 1980s. However, for multiple reasons the use of in vivo testing is still limited. This, coupled with an increasing need to assess the hazards of hundreds of pesticides and thousands of industrial chemicals, has led to calls for the development and use of new approach methodologies (NAMs) that make less or no use of animals and are efficient and predictive.
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