toxicology - News - safefood Knowledge Network2024-03-29T02:16:20Zhttps://safefoodkn.ning.com/profiles/blogs/feed/tag/toxicologyDeployment of a Novel Organic Acid Compound Disinfectant against Common Foodborne Pathogenshttps://safefoodkn.ning.com/profiles/blogs/deployment-of-a-novel-organic-acid-compound-disinfectant-against-2023-01-04T09:43:04.000Z2023-01-04T09:43:04.000Zsafefood Knowledge Network https://safefoodkn.ning.com/members/safefoodKnowledgeNetwork<div><p>Abstract</p>
<p><br />Background: The disinfection process represents an important activity closely linked to the removal of micro-organisms in common processing systems. Traditional disinfectants are often not sufficient to avoid the spread of food pathogens; therefore, innovative strategies for decontamination are crucial to countering microbial transmission. This study aims to assess the antimicrobial efficiency of tetrapotassium iminodisuccinic acid salt (IDSK) against the most common pathogens present on surfaces, especially in food-borne environments. Methods: IDSK was synthesized from maleic anhydride and characterized through nuclear magnetic resonance (NMR) spectroscopy (both 1H-NMR and 13C-NMR), thermogravimetric analysis (TGA) and Fourier Transform Infrared (FTIR) spectroscopy. The antibacterial activity was performed via the broth microdilution method and time-killing assays against Escherichia coli, Staphylococcus aureus, Salmonella enterica, Enterococcus faecalis and Pseudomonas aeruginosa (IDSK concentration range: 0.5–0.002 M). The biofilm biomass eradicating activity was assessed via a crystal violet (CV) assay. Results: The minimum inhibitory concentration (MIC) of IDSK was 0.25 M for all tested strains, exerting bacteriostatic action. IDSK also reduced biofilm biomass in a dose-dependent manner, reaching rates of about 50% eradication at a dose of 0.25 M. The advantages of using this innovative compound are not limited to disinfecting efficiency but also include its high biodegradability and its sustainable synthesis. Conclusions: IDSK could represent an innovative and advantageous disinfectant for food processing and workers’ activities, leading to a better quality of food and safer working conditions for the operators.</p>
<p><a href="https://doi.org/10.3390/toxics10120768" target="_blank">Full article here</a></p></div>Outcome of the pesticides peer review meeting on general recurring issues in mammalian toxicologyhttps://safefoodkn.ning.com/profiles/blogs/outcome-of-the-pesticides-peer-review-meeting-on-general-recurrin2018-09-06T08:00:00.000Z2018-09-06T08:00:00.000Zsafefoodhttps://safefoodkn.ning.com/members/safefood<div><div class="t m0 x6 he y19 ff4 fs5 fc1 sc0 ls0 ws0"><p>This technical report reflects the outcome of the mammalian toxicology experts’ meeting on general recurring issues noted during the EFSA peer reviews of pesticide active substances under Regulation (EC) No 1107/2009. The main issues identified were related to genotoxicity of products and principles of (Q)SAR and read-across. General presentations on the different EFSA guidance and EFSA developmental activities related to human health risk assessment of pesticides were given.</p>
<p><a href="http://efsa.onlinelibrary.wiley.com/doi/epdf/10.2903/sp.efsa.2018.EN-1485" target="_blank">Continue Reading</a></p>
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